It's doubtful that the Spaniard starts, we should continue to see the Jorginho/Gokhan Inler pairing, but it does seem likely that we'll see Lopez on the pitch at some point. If Napoli are trying to hold a slim lead later in the match or are trying to stem the tide of Chievo momentum against them (unlikely, but still), Lopez and his ball-winning mentality could come very much in handy. That's especially true if Inler's rough form from the Genoa match continues, but that seemed to be due to lack of recent playing time more than anything.
It'll also be interesting to see how The Hero Of Genoa, Jonathan De Guzman, is used. He could ostensibly replace either Jorginho or Marek Hamsik in the lineup, but neither player has done poorly enough to warrant a benching. Instead, we'll more likely see De Guzman used as a super-sub again, along with Michu, who's also still awaiting his first start in a Napoli kit.
The only player unavailable is Faouzi Ghoulam, who's still at least a couple weeks away from returning from a fractured arm.
Here's the full 22-man squad available for the first league match in Naples this season:
Goalkeepers: Rafael Cabral, Mariano Andujar, Roberto Colombo
Defenders: Giandomenico Mesto, Chrisitan Maggio, Henrique Buss, Miguel Britos, Kalidou Koulibaly, Raul Albiol, Camilo Zuniga
Midfielders: Gokhan Inler, Jorginho, Walter Gargano, David Lopez, Jonathan De Guzman, Dries Mertens, Michu, Marek Hamsik
Forwards: Jose Callejon, Duvan Zapata, Gonzalo Higuain, Lorenzo Insigne